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Old May 29th, 2008, 09:01 PM
vegasmisty vegasmisty is offline
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Question Milk Thistle for liver disease in cat

Ive just started our cat on Milk Thistle seeing her liver disease was being treated with Prednisolone and Clavamox but once these are used up the Vet will not renew them and said there is not much more she can do to help her so I did some research on Milk Thistle and it sounds like what she needs right now. It certainly cant hurt her seeing its herbal and I have researched those who used it for their cats, the results were very good for almost all of the cat owners. It removes the toxins and helps the liver cells regenerate.

Problem is on her first dose she foamed at the mouth and threw some of it up which I assume was because of the taste. Its liquid seeing she is a bear to give pills to. I guess I was hoping the taste was going to appeal to her but I was wrong.

Any suggestions on getting this in her without her having this reaction? She seems so stressed out while she's frothing. A liver supplement Denosyl in pill form was tried awhile back and she had the same reaction as the Vet had me crush it and give it to her in a very small amount of water.



Any suggestions?
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Old May 29th, 2008, 09:34 PM
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sugarcatmom sugarcatmom is offline
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Milk thistle does taste pretty bad, and on top of it, the liquid probably has alcohol in it, which cats really hate. What about trying Denamarin. It's a combo of SAMe and sylibin (milk thistle derivative). Unfortunately it's a rather large tablet and you'd probably have the same problem with the taste if you crushed it, but it's supposed to be quite effective for liver issues. Something else to consider is L-Carnitine.

What sort of liver disease does your cat have? Any ideas what's causing it?
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Old May 29th, 2008, 11:54 PM
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Dr Lee Dr Lee is offline
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sugarcatmom you took the words out of my mouth. Denamarin is a great medication, or actually nutriceudical. It is a combination of both SAMe (Denosyl) and sylibin (milk thistle).

This is from Plumb's Veterinary Drug Handbook:
"There are no reported absolute contraindications to silymarin in animals."
"There are no apparent contraindications to the use of SAMe."

Pretty great huh?!

Also, denosyl and thus denamarin are enteric coated meaning that you should NOT crush or even cut the pill. Enteric coating is a protective coating to help the medication pass the stomach without destroying the medication. If you split or crush the medication, the medicine loses a lot of efficacy.

Also Denosyl should be given on an empty stomach and Milk thistle should be given with food. The representative suggest that denamarin be given with a small amount of food.

Also, what type of liver disease does she have? What exactly is going on? I am confused on the short duration of prednisolone.
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Last edited by Dr Lee; May 29th, 2008 at 11:55 PM. Reason: added bolding and italics
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Old June 2nd, 2008, 03:38 PM
vegasmisty vegasmisty is offline
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Dr Lee,

We were told she has Feline Hepatic Lipidosis. She also has arthritis and bone spurs and the steroids were given to ease those problems.
They did want to to do a biopsy because she is estimated to be 10-13 yrs old and think this evasive surgery would be more harmful than helpful.
The main thing they tell us is to control it make her remaining time manageable.
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Old June 2nd, 2008, 11:23 PM
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Dr Lee Dr Lee is offline
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Quote:
Originally Posted by vegasmisty View Post
Dr Lee,

We were told she has Feline Hepatic Lipidosis. She also has arthritis and bone spurs and the steroids were given to ease those problems.
Have they talked to you about Cosequin? This is a very safe holistic medication for cat arthritis. It also comes as a sprinkle cap which makes administration very easy - just sprinkle it on the food. Below is a link to cosequin...
http://www.nutramaxlabs.com/products...ointHealth.asp

I would be concerned about the use of steroids with hepatic lipidosis. This is from a feline internal medicine specialist, "Glucocorticoids (prednisolone)result in the mobilization of peripheral fat stores -- this is something that you do not want to do with hepatic lipidosis." - Michele Gaspar, DABVP (Feline). Mobilizing peripheral fat stores can make hepatic lipidosis worse!

Tramadol may also be an alternative. Tramadol is a safe pain medication. It can be great to use because it is eliminated via multiple pathways and does not place excess stress on the liver. It is also very, very affordable.

Also I used to work in Las Vegas. I ran a four doctor practice there! Small world.
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Old June 9th, 2008, 05:09 PM
vegasmisty vegasmisty is offline
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Thank you Dr. Lee. She is not on steroids now but although she appears fine in many respects she has problems walking. If we hold her tail she will walk fine but if we dont hold her tail even lightly up in the air, she will fall and trail to one side or the other.
Her back legs work and she doesnt appear to be in any pain. She eats fine, goes potty fine, yet this problem which she had since coming home from the Vet over a month ago appears to not want to go away. The Vet stated she thinks her arthrtis might be the problem seeing its in her hind quarters along with the bone spurs.
She will literally drag herself to the food bowls or potty box.

I wish you were here in Vegas now. We have been to 2 vets and get different ideas on her problems and its so frustrating seeing we cant help her. Hubby is Military so we cant afford the constant $800 plus bills for her and still have no resolve or definitive answers.

Last edited by vegasmisty; June 9th, 2008 at 05:12 PM.
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Old June 10th, 2008, 07:44 PM
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Quote:
Originally Posted by vegasmisty View Post
...she has problems walking. If we hold her tail she will walk fine but if we dont hold her tail even lightly up in the air, she will fall and trail to one side or the other.
Her back legs work and she doesnt appear to be in any pain.... She will literally drag herself to the food bowls or potty box.
Much of what you describe, especially the "dragging" makes me concerned about a possible neurologic issue. Could you ask your veterinarian about that? A simple neurologic examination can be done in a room and can be charged as part of the examination fee. This would change a lot it that were the case.
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Old July 29th, 2008, 02:06 PM
vegasmisty vegasmisty is offline
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Just wanted to let you know that our beloved Torty passed away Sunday evening. She took a real quick turn for the worse very early Sun. morning and passed at 5:45 Pm Sunday.
We miss her dearly but know in our hearts she is better off. No pain, no discomfort, no more problems. Her liver disease was not cureable and we were told it was just a matter of time for her so deep down we knew her fate but it doesnt make it any more easier to take. She fought to stay with us but we kept telling her to let go.
Our other 2 cats know she is missing and I know they see our pain. I am hoping they dont take her absence too hard. Our male cat Brownie is so much more human than feline, he hates change. He got so sick when my husband was deployed 2 years ago that after almost $1000 in vet bills and 3 days at the vet and tests galore, they found nothing wrong with him. To this day they have no idea what caused his high fever and his vomiting.

Thank you again for being here for us who love our animals like our kids. They are part of the family no matter how short their time with us is and the family greives when they are gone.
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