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Old October 12th, 2008, 10:28 AM
cattychew cattychew is offline
Junior Member
Join Date: Oct 2008
Location: Melbourne, Australia
Posts: 12
Potential thyroid related neurological problems.

Hi, I'm kind of at a loss as to what to do right now. I should mention first up that I have been seeing a vet, but for reasons I will soon explain, have been going kind of crazy regarding the condition of my (soon to be, on October 28th) 11 year old Labrador, Lan.

I apologise for the length, but it is kind of an epic story.

It started at the end of May of this year when I noticed that Lan was having trouble chewing. She tends to be fairly tolerant of pain so it is hard telling when something is wrong with her. It turned out that she had a fractured carnassial tooth that needed to come out. And just previous to her operation, I noticed that she also had a lump in her chest. I mentioned this to the vet and he took some blood for analysis and decided it was an adenoma.

She then had an operation to remove both the tooth and the adenoma in June, but during the op the vet noticed a second lump and removed both for biopsy. One of the lumps was growing from her thyroid which he removed along with it.

The test came back that the second lump was carcinoma and after a few tests we found out that we were lucky because it hadn't spread.

Unfortunately, a while later she injured one of her hind legs. She has had a run of bad luck lately, it is almost unbelievible. It turned out that she had a ruptured cruciate and needed another operation. We were kind of broke having already just paid for her previous surgery so we kept her quiet and carried her up and down the steps at our house, while keeping her on a low fat diet. Sometime previous to the operation she injured her front leg and had a slight weakness in her other (non-ruptured) hind leg. The vet attributed the soreness in her front leg to compensating for the bad hind one since it was on the opposite side to the front. The back he said could be a torn cruciate since it is apparently not uncommon for them both to go.

It had been hard for the vet to diagnose the initial cruciate injury due to Lan not being very happy about being at the vets and she tends to tense up when he touches her so he was going to x-ray her before the operation to be sure.

The operation was performed at the beginning of September, at which time the nurse commented about the hair on her chest (where the cancer was removed) having not grown back properly. Some had grown back, but it was patchy. She thought that maybe it was due to scar tissue.

About a week after that she had begun putting some weight on her repaired knee and was bunny-hopping around. Things seemed to be improving and then all a sudden she stopped putting weight on the repaired leg, then a few days later she seemed to have trouble putting weight on her other hind leg. In the meantime the front leg, which was not completely right, had benefited somewhat from painkillers.

But one day about three weeks ago she tripped (or so we thought) and it seemed as though she had reinjured the repaired leg and blown the unrepaired knee. She was having a really hard time getting around for the two days following that and then one Saturday after carrying her outside to the toilet she couldn't support her weight and sat on the ground and messed herself. After everything that had happened, it just kind of ruined us.

The next morning our vet came to the house because there was no way we were going to be able to get her into the car without causing her a bunch of stress and potentially injuring her.

The vet took a look at her chest (with the patchy hair) and her coat, and then took some blood and slung her back legs in a towel so he could take a look at her walking. She would pull herself along on her front legs OK, but her hind legs were knuckling. He said that it seemed to be a neurological thing relating to the removed thyroid, or potentially some sort of spin or nerve damage.

When we got the test results back for the bloodwork it turned out her thyroid hormone levels were lower than they should have been and she was prescribed one and a half tablets of thryroxine twice daily and one tablet of macrolone once daily.

Almost the next day she started having trouble holding onto her bladder and my vet said that it was probably due to the medication, but had us bring a urine sample in anyway (which he had wanted us to do after looking at the blood).

The frustrating part is this, my vet then went on a holiday. Don't get me wrong, I don't begrudge the man a holiday but it made things kind of difficult for us, having to deal with another vet at the practice. Anyway, after nearly getting a bottle of medication designed to stop her from urinating the vet took a look at the urine sample and discovered she had contracted a urinary tract infection. He said that it probably came about due to the macrolene which is (as I understand it) some sort of steroid similar to cortisone.

The side effects of it (which she showed after a couple of days) were panting and excessive thirst. Which combined with the urinary tract infection has had my washing machine working overtime. By the way for the UTI he prescribed clavulox.

She has been on the macrolone and the thyroxine since the 29th of September. Sometime at the end of last week I noticed she seemed anxious and was crying a lot so I did a search online and discovered that some potential side effects of macrolone were anxiety. She was also noticibly down during the time of day previous to taking the medication. I spoke to another vet (since her regular one was still on holiday) on I believe Friday. He told me to not give her the macrolone for a couple of days and then give her half in the morning and half at night. I had her off of it for one day (Friday) that night she threw up her dinner along with (I assume) her dose of thyroxine and I was unsure about whether or not I should give her any more. I didn't, but after reading about the problems with coming off of macrolone cold turkey I gave her half of one Saturday along with her usual dose of thyroxine in the morning. Her anxiety started up again, and then when we took her to the toilet we noticed that she had started knuckling on her front leg, the same one which had given her trouble earlier.

Since the 29th of Sept. when she started taking the thyroxine she has had no noticeable improvement with walking, but I have been doing physio on her hind legs while she has been laying down and she will every now and again kick me. She can move her legs when you exercise them, but doesn't seem to be able to when she moves around on her bed.

So now she had three legs that are knuckling and I called the vet again this morning (Sunday). This is still not her regular vet, and now he thinks that she might have some nerve damage. I don't understand how this could be, because she has sensation in her feet and she can move her legs a bit, but just can't walk. So now tomorrow I am taking in another urine sample.

I had just been thinking that perhaps she needed her thyroxine dosage adjusted, but nerve damage? The thought is bothering me. I don't know if I can put her through more operations. She has never dealt well with being away from me. I haven't been apart from her for more than a month in 11 years.

I should also mention that when she leans on her front leg when laying down she falls onto her side and has trouble righting herself again. And after her regular dosage of a total combine 3 thyroxine tablets today, after fixing her foot she walked on it a bit when I took her to the toilet.

Something else, when she knuckles her front paw it is almost as though she is clenching it. I didn't notice her clenching her hind feet.

As for her other problems, I'm assuming the macrolene is causing her anxiety again after one day of broken up doses. She has completed her clavulox course (for the UTI) but this morning after she had her half dose of macrolene she started whining, then later tonight after the second dose she started again. I gave it to her at about 8pm, it's now 2am (I am sleeping in the lounge room with her) and she is still whining. Usually she'd be asleep by now. If I go and lay on the floor next to her bed she seems to relax a little. Her pupils are also pretty wide considering the light is on, she is panting a lot and I also have noticed that she has put a lot of the weight she lost back on even though we have been careful with her food.

I will be addressing these things tomorrow when I speak to the vet (our regular vet still isn't back from his vacation). But if anyone could offer any advice or any insight into any of this I would greatly appreciate it.

Again I apologise for the length, I realise that she is getting on a bit for a labrador, but it's just hard because she was starting to get better and now it's just one thing after another.

- Matt
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