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Old June 17th, 2008, 04:43 PM
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TeriM TeriM is offline
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Anyone tried previcox for pain/arthritis issues?

Lucy is my 12 year old yellow lab. She had definately slowed considerably in the last year or so and experienced a fair bit of stiffness which I attributed to her age. She was also "runover" quite badly by my other dog (100 lbs) and my mom's dog (75lbs) when she was standing on a blind corner and they came running full tilt around it and hit her :sad:. We almost had to carry her home (hard to do with 65 lbs) but she managed to limp her way back after a little rest.

Anyway ...... we were camping on the May long weekend and I administered her Meticam every morning as a preventitive as I knew we would be playing at the beach. I previously only ever gave it to her is she seemed especially stiff or sore. The daily dose made a remarkable change in her, she was much perkier, energetic and just overally much happier. It made me realize that she was actually experiencing some chronic pain :sad:, I felt so bad that I had not noticed it before .

So, she is now on daily doses of Meticam (am using the generic option currently). She also gets cartrophen shots once a month and glucosamine daily. My vet was talking about a fairly new pain/arthritis medication called Previcox that she thought we should consider for Lucy. Lucy does have a history of liver problems which could become an issue with the Meticam and those risks should be reduced with the Previcox.

Anyone have any experience with Previcox?
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Old June 18th, 2008, 12:25 AM
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Dr Lee Dr Lee is offline
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Previcox is one of the newest additions to the canine NSAIDs. The claim on Previcox is that it has the highest safety range of all NSAIDs. Metacam runs a close second. Overall I love Metacam - it is safe and easy to administer.

Some important things to consider.

1) NSAID response can be very individual. It is important to choose the NSAID that works best for your pet. The two attributes to look at for NSAID response are pain relief and lack of blood value changes or clinical signs. If your pet is responding well, without any signs of side effects and liver and kidney enzymes are not rising, then you may want to stay with Metacam. If you do not feel that Metacam is working or if the liver enzymes are rising, then you may want to consider Previcox.

2) NSAIDs work best for osteoarthritis if given every day. Furthermore Previcox was tested against several other NSAIDs (metacam, rimadyl and deramaxx). The relief of pain was fairly similar at 48 hours and 2 weeks; however, the patients on previcox received greater pain relief when on the previcoxx for 2 months when compared to the other medications. The other medications provided similar pain relief at 2weeks as at 2 months. So Previcox may have better long term affects. Again, individuals respond to each NSAID differently so this test does not mean that it is a better pain reliever for all pets.

3) EPA (Eicosapentanoic acid) is a type of omega 3 fatty acids (fish oil). When given in large enough amounts, it can relieve osteoarthritic pain to a degree similar to many other pain medications. It reduces inflammation and can be used with or without NSAIDs.

4) Tramadol is a very safe pain medication that can be used with patients with metabolic or endocrine disease. It is metabolized via different pathways as opposed to medications that must be cleared through the liver. This medication is also inexpensive. One disadvantage, when compared to the omega 3 fatty acids or an NSAID, is that it is only a pain reliever. It does not reduce inflammation or help improve function. However, when looking at pain relief alone, it is a great medication.

5) Liver supportive medications. Denamarin is a combination of SAMe and silybin. Both help support liver disease, regardless of cause. It can not only help support the liver disease but also help the liver handle an NSAID medication. Denamarin is a nutriceudical (SAMe is a liver enzyme that is naturally occurring and silybin is from Milk Thistle) and thus you are not adding in more 'chemicals' to your pet.

Hope this helps.
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Old June 18th, 2008, 02:40 PM
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TeriM TeriM is offline
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Thanks for that great information Dr. Lee . Lucy actually has a history of liver problems which is why we were considering some of the other options. About 7 years ago she got quite sick and was diagnosed with chronic active hepatitis, her counts were off the charts and the ultrasound showed her liver so small they could not even consider a biopsy. We placed her on antibiotics and ursodial and I chose to continue feeding a raw diet (my vet did want me to switch to prescription but supported my decision) and supplemented with many vitamins.

The great news was that when we retested her a few months later there was a huge improvement and within a year her values tested normal and continued to do so until about six months ago. Her liver enzymes when last tested were about 3 times normal so we did another antibiotic run and placed her back on the ursodial. I also give her milk thistle, vitamin E, acidophilus and digestive enzymes. In retrospect some of the symptoms she was showing I now believe might be attributable to pain issues instead (shaking, panting, wanting to be outside a lot). Since beginning the meticam regularly she has not had those problems again and has not experienced any other side effects.

She is due to be retested again and I will be doing that next week. I will also ask about starting the Denosyl. Do you have any opinions about the Denosyl versus Ursodial? Thanks again for the information!
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Old June 24th, 2008, 12:34 AM
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*bump*

Has anyone used this with their pet?
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Old June 24th, 2008, 03:40 AM
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Teri, I don't know anything about it but I found this....


http://www.fda.gov/cvm/Documents/N141230cis.pdf


http://www.cvmbs.colostate.edu/ivapm...vicox42006.htm
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  #6  
Old July 13th, 2009, 12:05 AM
mandy252 mandy252 is offline
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Previcox taken when on antibiotics..is this ok?

My poor lil 14 yr old lab has come down with what we believe to be Vestibular Syndrome.

Anyway, she was on previcox before all of this.
I've taken her to a vet, who said to stop taking the previcox while on the antibiotics (cephalexin).
I then went to my regular vet (as she was closed the days I needed her when the VS all began)..and she said to put her back on the previcox.

Well, when we stopped the previcox the first time..the VS symptoms started to go away, but feeling I should listen to my own vet, we put her back on the previcox and within a day she resorted back (if not worse) to her symptoms once again.

Anyway, I stopped the previcox and she's got about another 2 wks worth of cephalexin to go....what's your opinion of being on antibiotics while taking previcox?

Thanks
Jenn
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  #7  
Old July 13th, 2009, 04:03 PM
ScottieDog ScottieDog is offline
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Terri, I have a breed that has some liver enzyme issues. I have used both Denosyl and Denamarin. Here are some links with more information.

http://www.drugs.com/vet/denosyl.html
http://www.drugs.com/vet/denamarin.html

Last year, I had a dog with multiple health issues who developed bacterial hepatitis. She was given the denamarin with an antibiotic and her liver enzymes dropped 800-1000 points in one month (still elevated). This was a dramatic improvement as two liver enzymes were around 2000. She was given an NSAID to treat suspected bladder cancer and sadly, her liver was so damaged at this point the NSAID threw her into kidney failure and she passed. My dog had multiple severe health issues, beyond what you are seeing with your dog. I do understand wanting to use caution with medications and liver problems.

I also used denosyl for two Scotties and had success lowering the AlkPhos liver enzyme (tends to be elevated in this breed). A 6 month course pulled values from 1,200 and 1,500 to the 600 and 800 level. One dog was also tested (negative) for Cushings.

I've had success with the supplements and would not hesitate to use them in the future again. Good luck to Lucy.

Jenn (Mandy252), I also wanted to wish you luck with your doggie and vestibular. We are going through this with our 14-year-old. He was doing great, but had a mild relapse last week. We are concerned, and I just wanted to offer you a hug.
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Old July 16th, 2009, 09:40 PM
mandy252 mandy252 is offline
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I'll take the hugs and pass them to Mandy!

Thank you so much for the hugs!
I sure could use them right now.

As written in my email to you (which I just sent):

"I went to the vet again today. She said considering the rapid eye movements have ceased and the head tilt is only on and off she's thinking it's not vestibular anymore but could be an inner ear infection, brain tumor or blood clot.

She examined her ear and realized how inflammed it was and also the amount of gunk in it and said we'll treat it as that for this week.
She put her back on apo-amoxi instead of her cephalexin.

Anyway, she said if it's not cleared up in a week we are left with only two choices.

1. We could get her referred to the vet college and have her ear swabbed to find out what type of infection it is, and/or have an MRI or CT scan done.

2. She said if I choose not to go the college route then its not fair to let her go on like this and put her down as her quality of life is not what it should be.

Basically she made it sound like if the infection don't clear up this week, she doesn't want to deal with us anymore as I'm prolonging the inevitable. Either get her ear swabbed, find out the reasoning, or put her to sleep. Sheesh I really really don't want to put my dog down cuz she has a major ear infection!!

She also gave me a script for Bonamine (meclizine). Well I went to the pharmacy to have it filled and they told me they discontinued this drug in canada over a year ago! Sheeesh!!! So the pharmacist suggested giving her a gravol for the night and call the vet tomorrow to tell her about the discontinuation."

So here I am now, starting her on the new antibiotics and going to pray so hard that this works.
I know her ear is infected, you can see it and smell it!

Gosh I love her, she's been in my life for 13 years and even though I know one day I must say goodbye, I am far from ready!!!!

Thanks for the reply and the hug...I wish you the best for your pooch!

Jennifer
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Old July 17th, 2009, 04:05 PM
ScottieDog ScottieDog is offline
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Jennifer,

I saw your message. I don't know if I'm the person you were trying to email, but I don't remember leaving an email at this site. I want to encourage you not to give up hope. Sometimes this is all we have!

The medication prescribed is Bonine (an over-the-counter travel sickeness medication available in the US.--I'll need to remember that it isn't available in Canada if I ever come visit--I get car-sick myself.)
http://www.drugs.com/pdr/bonine.html

My mother has migraines with vertigo and her doctor prescribed a medication called antivert:
http://www.rxlist.com/antivert-drug.htm

Both these medications are meclizine HCl. I'm very surprised some form of this isn't available in Canada.

If the ear stinks something is going on. Personally, even though your dog was prescribed an antibiotic, I would request a swab/culture of the ear to find out what type of bacteria is involved. By doing this, "they" can determine the appropriate antibiotic to use. Not every infection responds to every antibiotic. And very bad infections do not always clear up in one week's time. (I saw this with my beloved Scottie girl who had a UTI that took 4 months of antibiotics to clear up so she could have bladder surgery.)

I believe that the MRI/CT type scans require anesthesia. It is not a choice I would make at this point for my 14-year-old. Right now, he is doing pretty good, but, since he had a re-lapse or re-occurrence my vet does feel that more are highly likely. Right now it is a day-at-a-time. We did have the eye movements with the second episode (9 days after the initial). My dog is deaf and when I woke him for a walk it really startled him and he jumped 2 inches off the floor and the episode started. He wasn't as fearful. I know my vet asked about the eye movements, since he said that the eye movements tend to appear with vestibular, but don't with strokes or brain bleeds.

I'm going to include a couple of links that helped me when Mac came down with this:

http://lassiegethelp.blogspot.com/20...-light-on.html

http://dog-care.suite101.com/topicli...bular_syndrome

When I discussed my dog's relapse with my vet, I could tell he wasn't happy that a second episode happened so close to the first. He did assure me that if he was able to eat and drink that he was not suffering. Keep doing research. There is some question as to whether the vestibular attacks can be triggered by antibiotics. My dog had finished a course of clindamycin the Friday before his Monday attack. My dog also developed sneezing and a snotty nose a few days after the initial attack. There's also some question as to whether respiratory infections/issues can trigger attacks. The peripheral vestibular disease is caused by an inflammation of a nerve in the ear. From my research, the dog's sense of balance basically needs to "reboot" like a computer. This can take days or weeks. The following quote is from a golden retriever rescue group:
"Please note that a serious inner/middle ear infection (which can occur without the customary smelly ear) has the same severe and frightening symptoms. An infection can usually be cured with antibiotics and the dog have a complete recovery. As always, check with your vet. "
http://www.ygrr.org/doginfo/health-vestibular.html

The dog in the story above took 5 months to recover. Your Mandy is in my prayers. It is so hard, but stay strong for her.

You are right. We are never prepared to say goodbye. I know that at 14, my sweet little guy is in his twilight and I love him more every day. He is the first dog I've ever shared my life with--and because of him, I have my life-long passion for dogs.

-Sandra (ScottieDog)
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  #10  
Old July 18th, 2009, 10:53 PM
mandy252 mandy252 is offline
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Thank you for your input

The way my vet talked, that I would have to send her to the vet college to have the swab done. Does she need to be under anesthesia for that?
I just didn't understand why she couldn't just take a swab there at the office, but I suppose if it's deep down she can't reach it.

She just had 2 good days and now today is bad again. Her dizziness is back, so she's on gravol now. (it's canadian, so im finding out, for travel sickness, over the counter).

I have noticed a runny nose now and then and a sneeze also once in awhile along with her eyes will water on occasion. (I feared the watery eyes were her crying from being sad and sick, poor dear). Although these aren't very frequent.

Like you, if I startle her or if she's had a hard time walking and it tires her, her rapid eye movements return a little, and if i lay her on her good side, the eye movements are there.

Anyway, I will take it one day at a time, but my vet seems to be giving up on us. She said that if this apo-amoxi she is on now doesn't clear up the ear by this Thursday, she is giving me only two options...1. I send her to the vet college by referral, or 2. to have her put down.

With her dizziness she is havin a hard time walking. She's eating,drinking, goin to the bathroom and waggin her tail....I don't understand the reasoning behind the second option. She said she don't want to see this go on for months...but what if it is something that maybe months is what it needs to take??? I have the patience to help her walk, drink the water and go to the bathroom (she's 92lbs and yes requires some help from my hubby too), so why don't she have the patience to help us through this????

Sorry, a little frustrated here, and don't plan on giving up on her so easily...like you, this is the first dog I've shared such a long part of my life with as I've had her since she was 6 weeks old, she turns 14 on Feb.14, 2010...I would love to be able to have her celebrate that golden birthday!

Thanks for listening and the hugs for my Mandy...she loves them!
Best wishes for your pooch too!

Jennifer
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