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His skin may be sensitive, as mentioned above. If he has fleas, that could be adding to his discomfort. Please ask your friend to use a flea remedy from the vet, it's called Revolution and you apply it to the back of the neck, right on the skin. She should avoid OTC products such as Hertz collars, they are full of harmful chemicals and often don't work.
I have one of those brushes, you have to use them carefully because the wires can dig into the skin. Maybe try one that is more like a human hairbrush, with softer bristles.
My cats do the same thing, grabbing at the brush, chewing on the business end, just generally interfering. If they really object, I just try later.
If he gets alot of hairballs, your friend would be doing him a favour by brushing him regularly, less hair will end up in his tummy.
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