Dogs do tend to urinate less frequently as they mature from puppyhood. In addition, the diphenhydramine HCl can cause decreased urination, so what you're seeing is probably a combination of Chloe's bladder maturing and effects of the antihistamine.
If you're concerned about it, though, you could always call the clinic and pose the question. If they don't think it's anything out of the ordinary, the phone call sure would set your mind at ease.
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