We thought or think that Luke has Lupus. Only because his nose was discoloured and really dry all the time. I did a bit of research on it and found some herbal remedy online that helped. It was from Natural Canine
http://www.naturalcanine.com/html/lupus.html
We used the cream and the pills. It actually really helped clear it up. The vet recommended we do testing. How they do that is punch little pin like holes into his nose to take samples and test it. Then if it is Lupus to put him on antibiotics for his whole life. I wasn't too keen on the idea. The only thing that affected him was his dry discolored nose.
Now we are careful about taking him outside when its sunny. He wears sunscreen on his nose! The sun makes it worst. And we give him Omegas and vitamin E oil (daily) that he takes in gel tabs and also we put it topically on his nose once a week or once every 2 weeks. He is fine.