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I'd give it a little longer to work. Metronidazole works quickly but 12 hours is probably too soon to see results. If your dog isn't markedly improved in another 24 hours, I'd at least call the vet back and see if they need to do more tests.
Was there a diagnosis before the metronidazole was prescribed? How much blood is in the stool? Some things to watch for that would indicate a serious problem include your dog going off his food, sitting or lying hunched as though in distress, unexplained panting and/or shaking, white gums, or a black tarry-looking stool. If the gums get white or the stool becomes tarry, treat it as an emergency and get your dog back into a vet ASAP.
The cost difference comes into play because vets are allowed to determine their own markup on medicines. For those drugs that are the same in humans and canines, if you can get your vet to write a prescription for you, you can often fill it at a human pharmacy for much less than you'd pay through the vet clinic.
Good luck and keep us posted on your dog's progress!
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