It's called "tough love". Just don't have Smokey in the bedroom at night at all. We have the same problem and both hubby and I need a good night's sleep to function properly, so our cats go to our basement-level recreation room at night. Set up Smokey's food, water, litter box in another room (rec room, bathroom, spare bedroom, laundry room), or if you don't have a spare room use a large dog crate. Our cats do get a snuggly cuddle time in bed during a rest before dinner. Give Smokey lots of cuddles and attention before
you go to bed and feed him his evening meal then.
Obviously, he's missing the companionship of his brother. Have you considered a kitten for a new cat friend? An adult cat usually gets along better with a kitten than an older cat (say over 8 mos.). Generally speaking, two cats do better than one alone, as they can stimulate and play with each other.