Originally Posted by rjesak
Oscar definitely gained weight while he was on pred (in this case he was underweight so we considered that a plus). He also went a bit mean. We've had big problems with aggression toward his younger brother ever since he went on - even though he's off the pred, he learned this bullying behavior and we're still trying to work it out of him. It also (most likely) is responsible for the calcium oxalate stones he just had to have removed from his bladder.
I don't think we had a choice in Oscar's case (we were fighting asthma so options were limited) but he's a completely different cat since he started on pred and, even though he's off now, a lot of those changes took root.
I'm not sure about alternatives for pain - my vet uses Metacam which has it's own issues, but I wouldn't use pred if you didn't have to!
I had my boy (Tigger) on pred. for about 2 days and it did the opposite. He was distant, won't sleep with me, just really not my cat, so I took him off that and now use antihistamines for the coughing and sneezing which I presume is due to allergies. That works great as long as I can get him to eat the pill pocket without tasting the pills. Once he tastes the pills it becomes a game of how to get him to eat it without knowing. The antihistamines taste terrible, especially Benedryl ( which I find is the better one).
Don't know if that would help with your guy?