FIBROSARCOMAS at Rabies Vaccine Injection Sites in Dogs
Below is the Journal of Veterinary Medicine abstract of an important documenting fibrosarcomas at presumed rabies vaccination sites. Some veterinarians deny that dogs develop cancerous tumors at vaccination sites --this study suggests otherwise! The researchers used the presumed injection sites of rabies vaccines in the study.
The following quote is from the full study text: "In both dogs and cats, the development of necrotizing panniculitis at sites of rabies vaccine administration was first observed by Hendrick & Dunagan (1992)."
Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas
Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291(6)
Vascellari M.; Melchiotti E.; Bozza M.A.; Mutinelli F.
 Address of authors: Istituto Zooprofilattico Sperimentale delle Venezie, Histopathology Department, Viale dell'UniversitÓ 10, 35020 Legnaro (PD), Italy;  Corresponding author:, Tel: +39 049 8084261, Fax: +39 049 8084258,
Fifteen fibrosarcomas, surgically excised from presumed sites of injection in dogs, and 10 canine fibrosarcomas excised from sites not used for injection were histologically and immunohistochemically compared with 20 feline post-vaccinal fibrosarcomas. Canine fibrosarcomas from presumed injection sites were of grade I (3), of grade II (4) and grade III (8). Two fibrosarcomas from non-injection sites were of grade I, four of grade II and four of grade III. Feline samples were classified as grade I (2), grade II (4) and grade III (14). All fibrosarcomas from presumed injection sites of both species showed lymphocytic inflammatory infiltration located at the tumour periphery, while two canine fibrosarcomas from non-injection sites showed perivascular inflammatory infiltration within the neoplasm. All samples were immunohistochemically examined for vimentin, smooth muscle actin, muscle specific actin and desmin expression. All tumours were positive for vimentin. Ten canine fibrosarcomas from presumed injection sites and all feline samples contained cells consistent with a myofibroblastic immunophenotype. Aluminium deposits were detected in eight canine fibrosarcomas from presumed injection sites and 11 feline post-vaccinal fibrosarcomas by the aurintricarboxylic acid method. The present study identifies distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection sarcomas not only in cats, but also in dogs.
Document Type: Research article ISSN: 0931-184X
DOI (article): 10.1046/j.1439-0442.2003.00544.x
SICI (online): 0931-184X(20030801)50:6L.286;1-