I add it to the drinking water when I have a new foster come in, helps if the rescue or Valentin is stressed and does not affect them if not stressed.
Can also be administered directly into the mouth. For situations I know are going to stress Valentin, I put a few drops on his head and rub in beforehand. Works anywhere the blood vessels come close to the surface, Ear flaps are good too. It also comes in a cream form, which I find useful for delayed release.
Love me, love my dogs