Tierce the Shiba is on Prednisone for his seasonal allergies. It's sure better than having him scratch himself miserable. I would much rather a dog have a good quality of life now than having a miserable (longer?) life. I notice that he drinks a lot more than he used to and tends to be a little more reactive towards other dogs - not enough to be serious, but enough that I watch his interactions carefully.
He's been on the 'zone for about a month now and so far, so good.