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Need help!! Cysts

swtnhpy
September 12th, 2009, 02:55 PM
Let me give you a little background. Siamese Lynx-Point,spayed 8 yrs old, no prior medical condition other than 2 UTI's. Presents with coughing, sneezing, and nasal discharge. Given Amoxil for RI for 7 days, went away for 3 months... came back ...given another dose Amoxil drops for 10 days. Symptoms came back 1 month later Given another med for 10 days and on 7th day quit eating and still drinking. Day 9 quit drinking on day 10 took to vet,Chest Xray showed what looked to her to be starting of pnemonia (pneumonia), bloodwork showed elevated WBC's and dehydrated. She was admitted with IV fluids and given 3 doses of antibiotics via injection over 2 days (day before Christmas Eve and Christmas Eve), sent home Christmas Day with liquid meds for 8 days. Seems to be getting better everyday (playing and acting normally), no more sneezing or nasal discharge, started eating (only tuna) on her own the day of hospital discharge. Since discharge have gotten her semi broke from just tuna and she started eating her reg. food again, Friday afternoon/evening noticed her after her nap came out with a lump on her forehead and swelling on one side of her face with same color nasal discharge. Vets were not in so took her in this Monday am as her swelling didn't get worse. Vet did 2 head xrays and says tumor. Put her on prednisone and Baytril to prevent secondary infection.

UGH I could not go to MedVet, they wanted $320 for initial visit and another $220 for a rhinoscopy. This has been one disappointment after another. I went for a third and fourth opinion. NOTHING!!!! "WE HAVE NO IDEA WHAT THIS IS" She was tested for FiLV, FIV, Lupus, and many other diseases. All to be negative. We tried anti-virals, anti-fungals, steriods, antibiotics (every one that is approved for use in cats). Her face swelling has never went all the way down. So finally we decided to try a punch biopsy of her bump on her head between her eyes, results were inflammation. We are now in September, in August she got one bump on her back, it started getting bigger and was seeping yellow fluid, She went in on Tuesday for removal and biopsy, result was round cell neoplasia (which vet said is abnormal tissue, not cancerous yet). Took her to the vet at 830am for surgery, checked her over head to toe before I left the house. She had that large cyst (one being removed), smaller one right above it, one on the base of her tail, and one on her belly as well as her face swollen what I would classify as medium swelling with no nasal discharge. I called to check on her at 6pm they said she was resting comfortably so I thought..what the heck, I'm going to visit her. I walked in to find what was the most devestating site! She was COVERED in tiny bumps (some looked like blisters) all over her back where she was shaved, a very large blister looking thing in her right ear, paw swollen and so much green and yellow snot coming out of her nose that she couldn't breathe as well as her face swollen to the point of almost not being able to open her eyes. I was livid!!! called the vet in and said....I dropped her off 10 hours ago and she didn't have any of this...Pardon my french but what the hell did you do to my cat?? They said...well maybe she had an allergic reaction to something. PUt her on Benadryl when you get home and see. I couldn't get it down her to be honest so I have no idea if it would have worked. They sent her home with steriod drops for her nose(refill) , prednisone shot.

NOW...as of today, she is itchy, (loves it when I massage and scratch all those bumps), her facial swelling is NOT going down at all, her bump that was the size of a pea when I dropped her off was the size of a dime when I showed up to check on her, it has not gone down at all. BUT...the weird thing....She has no bumps on her body where there is fur, it is all located where she was shaved.

HELP HELP HELP

chico2
September 12th, 2009, 04:24 PM
I am so sorry,I have no help to offer,maybe someone else does.
To me,it seems like a severe allergic reaction to something,but what??
I hope you get answers and your cat will get better,I can sooo understand your frustration,poor you,poor kitty:sad:

swtnhpy
September 12th, 2009, 05:05 PM
I thought of that but she has and will only eat Iams Original or tuna. That's it her whole life. I thought maybe it was the tuna so I stopped giving it to her and it didn't get better. The only thing that was noticed on her bloodwork was low WBC, low BUN. Everything else was normal.

I'm uploading pics if anyone wants to see them. http://ckwebsitedesigns.com/images/SAPPHIRE/

Love4himies
September 12th, 2009, 07:14 PM
I am sorry to hear about your kitty. I have no advice but "this forum does" have an excellent vet who does come online every once in a while.

I will PM him and ask him to take a peek at your post. He may have some suggestions on where you go from here.

swtnhpy
September 12th, 2009, 07:47 PM
Oh WOW...that would be sooooo awesome!!!

Dr Lee
September 12th, 2009, 10:00 PM
...biopsy, result was round cell neoplasia (which vet said is abnormal tissue, not cancerous yet).

BUT...the weird thing....She has no bumps on her body where there is fur, it is all located where she was shaved.

I am sorry for all that you and your cat are undergoing. It sounds very frustrating to say the least. Thanks Love4himies for the PM.

While I have not read the histopathology (biopsy report) in full, I am concerned on the term "round cell neoplasia". The definition of neoplasia is 'new growth' and applies to abnormal proliferative growth. The term neoplasia can often be interchanged with the words tumor and mass (and cyst if it is fluid filled). If the neoplasia, or new growth of cells, is not harmful then it is considered a benign mass. If the neoplasia is aggressive, then it is termed as cancer. The level and form of aggression with cancer ranges widely.

This is a response from a veterinary oncologist answering a question posted by a veterinarian:

"Discrete cell tumors = round cell tumors -- the terminology is a bit more precise as carcinomatous cells may appear round. The primary differentials are MCT [Mast Cell Tumor], lymphoma, TVT [Transmissible Venerial Tumor], and histiocytoma, classically. Melanoma, plasma cell tumor, and occasionally others might find themselves in this group depending on who is doing the writing.
Whether the cutaneous and colonic disease are the same I sure can't tell from here. Get a definitive diagnosis, not just the discrete cell tumor family designation, and you'll be in a much better position to advise your client..." - Bob Rosenthal, DVM, PhD DACVIM (SAIM, Oncology) DACVR (Radiation Oncology)


This is an excerpt from the following website: Round Cell Tumors (http://www.vet.uga.edu/vpp/CLERK/Nesbit/) :
"Canine round cell tumors consist of discrete cells that are round to oval in shape (8). They include mast cell tumor, histiocytoma, plasmacytoma, lymphoma, and transmissible venereal tumor." - Elizabeth A. Nesbit, DVM; Perry J. Bain, DVM, PhD; Nicole C. Northrup, DVM, and Kenneth S. Latimer, DVM, PhD

Finally here is an excellent website source (DVM 360 on Differentiating the Round Cell Tumors (http://veterinarycalendar.dvm360.com/avhc/Medicine/Differentiating-the-round-cell-tumors-Proceedings/ArticleStandard/Article/detail/599826)) which states: "Round cell tumors are commonly detected as cutaneous or subcutaneous masses. However, the majority of these tumors also appear in other locations. More differentiated tumors have very unique features that help to identify the specific type of neoplasia. However, poorly differentiated round cell tumors can be very difficult to identify..." - Mary Jo Burkhard, DVM, PhD, DACVP


All of these statements place round cell tumors as representing a group of tumors which have a range in their prognosis. Some of the possibilities include aggressive cancers. (mast cell tumors, lymphoma, etc.. are types of cancer). Others might have a better prognosis.

My recommendation would be to have a consultation with a veterinary oncologist, even if you do not pursue any further testing, a consultation at least might prove very helpful to you.

The bumps may be a reaction to the clippers or an allergic reaction. Because of the round cell neoplasia, the surrounding skin may be more sensitive.

I do wish you the best of luck and hope that this helps. :pawprint:

catlover2
September 14th, 2009, 01:45 PM
Aw, poor girl! She does look miserable with her face so swollen. Do try to get her to eat something else than tuna....can you mix in some chicken meat for babies with a little tuna to wean her off it? Tuna, being a top predator fish, can be highly toxic with mercury poisoning. Has she been tested for mercury toxicity? Just a thought that her body's finally reacting to all the toxins in tuna.

You might try a can of Wellness "Sardine Shrimp & Crab Formula" I think she might like that, and try the Wellness Dry or Natural Balance dry kibble considered by many to be a better food than Iams. I do hope you can find something to combat these mysterious lumps.

chico2
September 14th, 2009, 03:57 PM
Saffire is a beautiful girl,I hope she can get some relief soon:pray:

swtnhpy
September 14th, 2009, 07:10 PM
I am getting her the new food tomorrow and also getting her stitches and getting a new bloodpanel done.

swtnhpy
September 15th, 2009, 04:22 PM
Ok, got the bloodwork back.

LOW
RBC 3.78
HCT 17.9
HGB 6.9
LYM 0.28
WBC 3.58

High
MCHC 38.7


MCV, MCH, RDW, NEU, MONO, EOS, BASO, PLT all normal

EVERYTHING I am looking up points to anemia, viral infection or septis

I am soooo at my wits end with this. Her FeLV and FIV are neg. But still showing signs with low WBC and RBC of being FeLV. She has NEVER been around another cat. EVER! She has had her boosters. The only time she has ever had any contact whatsoever with an other animal other than my own was when she went in for pnemonia and stayed overnight Xmas Eve and the next day. This is soooooooo frustrating. Her face is now sooooo swelled that her lil eyes are watering

swtnhpy
September 28th, 2009, 05:53 PM
I had to put my Sapphire to sleep today. This had progressed so fast, she had lymphedema in her hind legs so bad over the last week that she could no longer walk. She quit eating and drinking last night. She passed away quickly and peacefully.

Testing is being done on her biopsies for further studies to prevent some other family from going through what we did. Thanks for all your support.

shirley1011
September 28th, 2009, 06:07 PM
I am so sorry to hear about your kitty. Rest in peace.

TwinTails
September 28th, 2009, 10:25 PM
I am so sorry for your loss :sad: Rest in Peace Sapphire :candle: may you run pain free and happy :cloud9:

catlover2
September 28th, 2009, 10:58 PM
My condolences on losing the battle with beautiful Sapphire's mystery disease. At least she is no longer in pain and at peace. You did all you could for her. Do give us an update of what the vet's think what happened to her.

Shaykeija
September 29th, 2009, 08:36 AM
I am so sorry for your loss. Know that your little cat was loved...

Love4himies
September 29th, 2009, 09:18 AM
I am so sorry, swtnhpy. Please take peace in knowing she is no longer in pain.

Please keep us posted on any new developments you learn on her mysterious illness.

:grouphug:

ScottieDog
September 29th, 2009, 09:25 AM
I am so sorry for your loss. It is very hard. Know that your sweet Sapphire is no longer in pain and patting butterflies at the Rainbow Bridge. I know your heart is really hurting right now. It is so kind of you to want to help other families facing this illness.

:candle: Sweet Sapphire :angel2: