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March 14th, 2006, 08:00 PM
My giant schnauzer was just diagnosed with cushings disease. I just received the perscription for lysodren and on the lable it says to give her 500 mg bid. the vet told me to give her 1000 mg bid. she weighs about 95 lbs, it is the induction phase. I am concerned as I am aware that it can put the dog into Addisons. What is the normal dosage for the induction phase?

March 14th, 2006, 08:02 PM
I think you should call your vet and ask him asap before you do anything. Unfortunately, there are no vets here to answers questions.

March 15th, 2006, 08:04 AM
My beagle is also cushingoid. She just finished her induction/loading phase is now on her maintenance dose. I would call your vet clinic to confirm the dosage. You are better to be safe than sorry.

I know of a great website that offers a lot of advice to owners of cushing dogs. They have helped me a lot during the last couple of months.

You should have also received some prednisone pills just in case too much lysodren is given. Your vet should have also given you all the signs to look for and you should also be in touch with the vet everyday during this induction phase. Communication with your vet during this time is extremely important.

I will pm you some really good websites.

March 15th, 2006, 09:45 AM
I tried to send you a pm but couldn't. Here is a link to a website that will offer you a lot of valuable information regarding cushings and its treatment. The members all have dogs with cushings and have helped me tremendously.

March 15th, 2006, 09:12 PM
I did call and talk to my vet again. I was freaked out by all the warnings with the meds and the possibility of overdoing it and putting her into Addisons. He put me a little more at ease, and explained the sighs to watch for a little better and he did tell me if I have any doubt about if she has had to much, give her the prednisone. He said that I know my dog better than anyone. I have to start her on Firday. hoping that she will reach the end of the induction phase tues or so, when he is back in the office. He is going to start calling me monday to check on us. How long did it take your dog to reach that magic level? What were the signs you saw? He did confirm that I was to give her 1000mg bid, how much did you give your dog?
I appreciate your information, and the web site, I am sure I will have a thousand questions, and I cant believe how stressful this is. I work with life and death all the time. I work in a trauma ICU and ER. but this stress is much different, it is mine.
thanks again

March 15th, 2006, 09:53 PM
So sorry to hear your furkid is sick. Luckily she has you to love and care for her. Once a "routine" of meds and tests settle in and you feel more confident about what you know and don't know, what you can and cannot do - I'm sure your stress level will drop considerably. Hugs to you both !

March 16th, 2006, 08:25 AM
I know how you are feeling right now as I went through the very same thing when we started the Lysodren therapy. It is scarey, but you are doing the right thing. Leaving Cushings untreated can cause many complications. I would report any slight change in Misty's behavior to our vet who helped me through that time.

Misty is only 32 lbs, smaller than your dog so she received less of the Lysodren. Also, because she tends to react quickly to meds we started slowly with her. The first time we tried induction, we stopped the Lysodren too soon. We thought she was loaded, but her 1st ACTH Stim Test showed that she was not. We started her on Lysodren again at a higher dose, I think 1/2 pill in the morning and 1 pill in the evening per day until we saw signs that she had been "loaded".

Her signs were subtle. We watched her for any of the signs that we were told to watch for. She was pretty hard to read though. She has always loved her food, so that didn't change much. What happened was that one day there was some bread on the living room table and she didn't make her usual grab for it. She also didn't raid the garbage on her way to the backyard or back into the house. When I spoke to the vet later that day, he told me not to give her any more Lysodren until we tested her again. Good thing because that night, we noticed a drop in her water consumption. She had her ACTH Stim Test a few days later and she was bang on, she was loaded. We then started her maintenance dose and she has been on that now for a couple of weeks. She is having another test done on April 1st to check her levels again to make sure the maintenance dose is working or to check if we need to adjust it slightly.

It does get easier as you become more confident in what to look for. You know your dog better than anyone and will notice the changes. The most common are a decrease in appetite or water consumption. My vet told me that the vomiting and diarrhea usually happen when the other more subtle signs are missed. It may help you to keep a diary of everything that you notice in your dog. Doing this will help when you report back to your vet.

Please do read all the links that were referred to you on the other site. They are very helpful and will put you more at ease. If you have any questions, I'm more than willing to help you in any way I can.

March 26th, 2007, 08:19 PM
I wanted to update on Nike. It has been a year since I posted here, I did go to the link for and received great help from the people there and still frequent their site. Nike has been doing wonderful. Her cushings is under great control, her last stim was last week with a post of 2.8. Her water uptake did not go down once the cushings was under control. It originally dropped for about 2 days then went right back up. She continued to drink 2 gallons or abt 8 ltrs in 24 hrs. My vet sent us to an internal Med specialist. we tried getting her cortisol very low again to see if that was it, again her uptake dropped, but only for a couple days. We tested all else that it could be and then did a water deprivation test and she was then diagnosed with Diabetes insipidus.
She now is on 1000 mg of Lysodren 2 times per week and 1 drop if dDAVP in her eye BID. She had some joint issues as she tore her ACLS a few years ago and now has a little arthritis, but is on meds as needed for that. It is hard to believe it has been a year. I want to thank those who responded to my desperate note. I was reading back on my first post to and the administrator suggested I come back and let you know how Nike has done.
thanks again for all your help. These forums are wonderful.
Sharon and Nike

March 27th, 2007, 01:27 AM
Thanks for the update :) .

March 27th, 2007, 01:09 PM
It was nice of you to update. Glad to hear Nike's cushings is under control. :highfive:

BTW, I don't think you were ever welcomed to the forum so "WELCOME" and I hope you stay and post pics of Nike. :)

March 27th, 2007, 05:04 PM
thanks for the welcome;
I was kind of a mess when I was here before and I really did appreciate all the advice I received. I posted a pic of Nike as the avatar, thanks for asking.

April 13th, 2009, 07:09 PM
Hi All.
I just looked back at it has been a year, again, since I last posted. Nike is still doing very well. She is now a 12.5 year old Giant schnauzer and has had Cushings for who knows how long and been treated for over 3 now. She still grabs her toys and brings them to me to play tug with her, she is eating well and with her DDAVp her PU/PD is totally under control. She also has been diag with DI, thus the DDAVp. I just had my male giant who is now 8.5 diagnosed with DI as well. For being such a rare condtion I somehow ended up with 2 dogs with it.
It was Beaglemom here that sent me to the forum site. I have been there for the past 3 years. The site has had some trouble and is shut down, when you type in the address now it takes you to an advertisement page and when you click on any of the ads you end up with all kinds of viruses. So wanted to warn any from here not to click on any of the ads if they try to go to the site. Currently the cushings site has space on the Diabetes site, Natalie has been great and allowed us access on her site.

You will need to register there to post there. We have lost many members as the site was there then gone. We are trying to let everyone we know about where the people from the site are now collecting and since it was this site that helped me find it I wanted to be sure anyone here interested or already a member on the CC forum can find us.

Thanks again for all you do for others, and again for the help you gave me when I was a over the top newbie to cushings
Sharon, Nike and Kenai
PS just added a couple pics of my family